Early and late outcome of treatment with oral ibuprofen in preterm infants suffering from patent ductus arteriosus: A randomized clinical trial

نویسندگان

  • Daraee, Gholamreza Semnan University of Medical Sciences, Semnan, Iran.
  • Ghorbani, Raheb Semnan University of Medical Sciences, Semnan, Iran.
چکیده مقاله:

Background and Objective: Nonsteroidal anti-inflammatory agents are the treatment of choice for ductal closure in premature newborn. This study evaluates early and late outcome, as well as the effectiveness of oral ibuprofen in the treatment of patent ductus arteriosus (PDA) in premature infants. Methods: In this clinical trial, all preterm infants below 37 weeks, with documentation of PDA were enrolled Infants were divided into two groups. The case group (19 patients) was treated with three doses of oral ibuprofen. Control group (19 patients) were under restriction of fluids (serum level of ⅔ maintenance). The rate of ductal closure, presence of pulmonary hypertension were determined at the age of one week, one month, 3 months and 6 months and intraventricular hemorrhage and periventricular leukomalacia (PVL) were detected at the age of one week and one month. The presence of retinopathy was checked at the time of hospital discharge and at the age of one month. Results: Ductal closure was achieved in all newborn of the ibuprofen group whereas in control group ductal closure rate was 16.19 (84.2%) (p=0.23). No case of pulmonary hypertension, PVL or retinopathy was observed in oral ibuprofen group. Regarding to other criteria such as hospital stay, intraventricular hemorrhage, sepsis, ventilator time dependence, pulmonary hemorrhage and mortality rate, no significant difference between the two groups was observed. Conclusions: Oral ibuprofen suspension may be an effective and safe alternative for PDA closure in premature infants. However larger studies are warranted.

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منابع مشابه

early and late outcome of treatment with oral ibuprofen in preterm infants suffering from patent ductus arteriosus: a randomized clinical trial

background and objective: nonsteroidal anti-inflammatory agents are the treatment of choice for ductal closure in premature newborn. this study evaluates early and late outcome, as well as the effectiveness of oral ibuprofen in the treatment of patent ductus arteriosus (pda) in premature infants. methods: in this clinical trial, all preterm infants below 37 weeks, with documentation of pda were...

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Oral paracetamol versus oral ibuprofen in the management of patent ductus arteriosus in preterm infants: a randomized controlled trial.

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The Effect of Oral Ibuprofen on Closure of Patent Ductus Arteriosus in Term Neonates: A Clinical Trial Study

Background The function of ductus arteriosus closes within a few minutes to a few days after birth in term neonates. In some cases, the duct remains open after birth, a condition which is called patent ductus arteriosus (PDA). PDA is associated with high rates of neonatal mortality and morbidity. The present study aims to evaluate the effect of...

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Oral paracetamol vs. oral ibuprofen in the treatment of symptomatic patent ductus arteriosus in premature infants: A randomized controlled trial

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Comparison of oral ibuprofen and indomethacin on closure of patent ductus arteriosus in preterm infants.

Although intravenous indomethacin and ibuprofen are widely used for closure of patent ductus arteriosus in premature infants, these formulations are unavailable in the Islamic Republic of Iran. In this study of the therapeutic effects of oral treatments, 20 preterm infants were randomized to oral ibuprofen (1 x 10 mg/kg, then 2 x 5 mg/kg at 24-hour intervals) or oral indomethacin (3 x 0.2 mg/kg...

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عنوان ژورنال

دوره 2  شماره 3

صفحات  6- 10

تاریخ انتشار 2016-07

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